Summer 1888: In a fancy house in London, a kitten called Scamp escapes through an open window and finds himself lost in the middle of the city. Across Hyde Park, a young girl called Beth is marching with thousands of other girls to protest the working conditions in the Bryant and May match factories. When Beth stumbles across the tiny kitten she finds that he belongs to none other than Miss Florence Nightingale, who is now indebted to Beth for returning her beloved pet.
So begins an unlikely friendship between the great lady, her mischievous kitten, and Beth the penniless orphan. But when Beth's sister Iris is struck down with illness in one of the poorest parts of London, can Beth, Scamp and Miss Nightingale find a way to save her before it's too late?